Aging with Grace

Written by David A. Snowdon, the book "Aging with Grace" is highly recommended. It can be bought at Amazon.com.

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"Since 1986, the author, an epidemiologist, has directed a research project dubbed the Nun Study. According to Snowdon, who previously studied Seventh-Day Adventists, religious group members make ideal subjects because of their similar and somewhat insular lives. Specifically, he has been tracking the lives of 678 elderly nuns who are members of the School Sisters of Notre Dame, to assess the effects of aging. Snowdon describes in detail a pilot study he conducted with the sisters in Mankato, Wis., on the link between level of education and disabilities related to aging. This initial research convinced him to expand his base to other convents and to focus primarily on Alzheimer's disease. The participants, ranging in age from 75 to 104, agreed to provide access to their medical and personal histories and, after death, to donate their brain tissue to the project. What distinguishes this study is Snowdon's decision not to maintain the usual "objective" distance from his subjects but rather to become emotionally involved with them. His commitment to treat them with "care and respect" is readily apparent in the many warm and sympathetic anecdotes and his expression of deeply felt grief when any of the sisters becomes incapacitated by Alzheimer's or dies. Among the project's findings is a clear correlation between a low rate of Alzheimer's and high linguistic ability. Snowdon has also found a positive relationship between the consumption of certain antioxidants (e.g., lycopene, found in pink grapefruit, tomatoes and watermelon), an exercise program and an optimistic outlook and aging successfully. Although the study is still under way, readers will certainly appreciate the early insights to be gleaned from Snowdon's human- (rather than statistic-) centered and compassionate story." (Copyright 2001 Cahners Business Information, Inc.)

What Sort of Exercise Can Make You Smarter?

By Gretchen Reynolds


Allow a laboratory mouse to run as much as it likes, and its brainpower improves. Force it to run harder than it otherwise might, and its thinking improves even more. This is the finding of an experiment led by researchers at National Cheng Kung University in Taiwan and placed online in May.

(...) For some time, researchers have known that exercise changes the structure of the brain and affects thinking. Ten years ago scientists at the Salk Institute in California published the groundbreaking finding that exercise stimulates the creation of new brain cells. But fundamental questions remain, like whether exercise must be strenuous to be beneficial. Should it be aerobic? What about weight lifting? And are the cognitive improvements permanent or fleeting?

(...) Why should exercise need to be aerobic to affect the brain? “It appears that various growth factors must be carried from the periphery of the body into the brain to start a molecular cascade there,” creating new neurons and brain connections, says Henriette van Praag, an investigator in the Laboratory of Neurosciences at the National Institute on Aging. For that to happen, “you need a fairly dramatic change in blood flow,” like the one that occurs when you run or cycle or swim. Weight lifting, on the other hand, stimulates the production of “growth factors in the muscles that stay in the muscles and aren’t transported to the brain,” van Praag says.

(...) “It would be fair to say that any form of regular exercise,” Chauying J. Jen says, if it is aerobic, “should be able to maintain or even increase our brain functions.”

Complete details at the NYT site:
http://well.blogs.nytimes.com/2009/09/16/what-sort-of-exercise-can-make-you-smarter/?emc=eta1